Phosphorus tribromide → 5-(Bromomethyl)-4-ethyl-1,3-thiazole

HRID 630275노트

반응식

HRID 630275 반응식
[CH2:1]([C:3]1[N:4]=[CH:5][S:6][C:7]=1[CH2:8]O)[CH3:2].[Br:10]P(Br)Br>ClCCl>[Br:10][CH2:8][C:7]1[S:6][CH:5]=[N:4][C:3]=1[CH2:1][CH3:2]

참가 물질

4

반응물 2

HCID 24614Phosphorus tribromideHCID 59589347(4-Ethylthiazol-5-yl)methanol

생성물 1

HCID 595893325-(Bromomethyl)-4-ethyl-1,3-thiazole

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of (4-ethyl-1,3-thiazol-5-yl)methanol (740 mg, 5.2 mmol) in anhydrous dichloromethane (35 mL) was added tribromophosphane (550 μL, 5.7 mmol). The mixture was stirred at room temperature for 2 hours. Dichloromethane was evaporated. The residue was dried in vacuo, affording 5-(bromomethyl)-4-ethyl-1,3-thiazole. The crude product was used without further purification.

후처리

  1. customDichloromethane was evaporated
  2. customThe residue was dried in vacuo

출처 및 근거

ORD 기록
ord-855cbde886284db99f5fceab79bba4cc
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09315521B2

반응 노트

불러오는 중…