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Diisopropylethylamine → (1-(5-(2-Fluorophenyl)pyrimidin-2-yl)-3-(methylsulfinyl)-1H-indol-6-yl)((S)-2-(methoxyethyl)pyrrolidin-1-yl)methanone

HRID 630474
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HRID 630474 반응식
CN(C(ON1N=N[C:11]2[CH:12]=[CH:13][CH:14]=[N:15][C:10]1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C(N(C(C)C)CC)(C)C.[F:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=1[C:41]1[CH:42]=[N:43][C:44]([N:47]2[C:55]3[C:50](=[CH:51][CH:52]=[C:53]([C:56]([OH:58])=O)[CH:54]=3)[C:49]([S:59]([CH3:61])=[O:60])=[CH:48]2)=[N:45][CH:46]=1.[CH3:62][O:63][CH2:64][C@@H]1CCCN1>CN(C=O)C>[F:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=1[C:41]1[CH:46]=[N:45][C:44]([N:47]2[C:55]3[C:50](=[CH:51][CH:52]=[C:53]([C:56]([N:15]4[CH2:14][CH2:13][CH2:12][C@H:10]4[CH2:11][CH2:62][O:63][CH3:64])=[O:58])[CH:54]=3)[C:49]([S:59]([CH3:61])=[O:60])=[CH:48]2)=[N:43][CH:42]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 81531DiisopropylethylamineHCID 671217(S)-(+)-2-(Methoxymethyl)pyrrolidineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 1186660891-(5-(2-Fluorophenyl)pyrimidin-2-yl)-3-(methylsulfinyl)-1H-indole-6-carboxylic acid

생성물 1

HCID 118676905
(1-(5-(2-Fluorophenyl)pyrimidin-2-yl)-3-(methylsulfinyl)-1H-indol-6-yl)((S)-2-(methoxyethyl)pyrrolidin-1-yl)methanone

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

HATU (144 mg, 0.379 mmol, 1.5 eq) and diisopropylethylamine (0.13 mL, 0.759 mmol, 3.0 eq) were added at room temperature to a stirred solution of compound 51e) (100 mg, 0.253 mmol, 1.0 eq) and (S)-2-(methoxymethyl)pyrrolidine (0.02 mL, 0.303 mmol, 1.2 eq) in dry DMF (10 mL). The reaction mixture was stirred for 30 min and then diluted with ice water (20 mL). The precipitating solid was filtered off and dried. White solid. Yield: 110 mg (88% of theory). Melting range: 143-146° C. HPLC (method 1): Rt=10.03 min

후처리

  1. filtrationThe precipitating solid was filtered off
  2. customdried

출처 및 근거

ORD 기록
ord-04b0fd6b1e46487b960c4292c41f0bc8
출처 데이터셋
uspto-grants-2016_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09315490B2

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