반응식
Br[C:2]1[CH:3]=[N:4][C:5]([N:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17]([N:19]4[CH2:24][CH2:23][O:22][CH2:21][CH2:20]4)=[O:18])[CH:15]=3)[C:10]([S:25][CH3:26])=[CH:9]2)=[N:6][CH:7]=1.Br[C:28]1[CH:33]=[C:32]([Cl:34])[CH:31]=[CH:30][N:29]=1.OC(C1C=CN=C(C2C=NC(N3C4C(=CC=C(C(N5CCOCC5)=O)C=4)C(SC)=C3)=NC=2)C=1)(C)C>>[Cl:34][C:32]1[CH:31]=[CH:30][N:29]=[C:28]([C:2]2[CH:3]=[N:4][C:5]([N:8]3[C:16]4[C:11](=[CH:12][CH:13]=[C:14]([C:17]([N:19]5[CH2:20][CH2:21][O:22][CH2:23][CH2:24]5)=[O:18])[CH:15]=4)[C:10]([S:25][CH3:26])=[CH:9]3)=[N:6][CH:7]=2)[CH:33]=1참가 물질
4
반응물 3
생성물 1
실험 절차
Coupling of (1-(5-bromopyrimidin-2-yl)-3-(methylthio)-1H-indol-6-yl)(morpholino) methanone and 2-bromo-4-chloropyridine analogously in an analogous manner as described for 289a). White solid. Yield: 1.7 g (79% of theory)
출처 및 근거
- ORD 기록
- ord-a1e9f8a7468e4ecc957336a85e4e9c85
- 출처 데이터셋
- uspto-grants-2016_04
- 특허 번호
- US09315490B2
연결된 노트
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