Pyrrolidine → (2S)-2-hydroxy-1-(1-pyrrolidinyl)-1-propanone

HRID 631761노트

반응식

HRID 631761 반응식
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.C[O:7][C:8](=O)[C@H:9]([CH3:11])[OH:10]>>[OH:10][C@@H:9]([CH3:11])[C:8]([N:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1)=[O:7]

참가 물질

3

반응물 2

HCID 31268PyrrolidineHCID 94386methyl (S)-lactate

생성물 1

HCID 11051776(2S)-2-hydroxy-1-(1-pyrrolidinyl)-1-propanone수율 84.4%

실험 절차

Pyrrolidine (39.25 g, 0.48 mole) was added dropwise to methyl-(S)-(−)-lactate (25.0 g, 0.24 mol) at 0° C. and the reaction mixture was stirred at room temperature for 3 days. The reaction mixture was concentrated under reduced pressure and purified with distillation to afford (2S)-2-hydroxy-1-(pyrrolidin-1-yl)propan-1-one 2 (29.0 g, 84%) at 150° C.-160° C. as light yellow oil.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. distillationpurified with distillation

출처 및 근거

ORD 기록
ord-fafa1e56c82c4d9db4286c2715c213ac
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321716B1

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