Hydrochloric Acid → 5-Methyl-6-sulfo-pyridine-2-carboxylic acid methyl ester

HRID 631999노트

반응식

HRID 631999 반응식
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]([OH:14])=[O:13])=[N:6][C:7]=1[S:8]([OH:11])(=[O:10])=[O:9].Cl.[CH3:16]O>O1CCOCC1>[CH3:16][O:13][C:12]([C:5]1[CH:4]=[CH:3][C:2]([CH3:1])=[C:7]([S:8]([OH:11])(=[O:9])=[O:10])[N:6]=1)=[O:14]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 866747445-Methyl-6-sulfo-pyridine-2-carboxylic acid

생성물 1

HCID 866747455-Methyl-6-sulfo-pyridine-2-carboxylic acid methyl ester

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To a mixture of 5-methyl-6-sulfo-pyridine-2-carboxylic acid (0.8 g, 3.69 mmol) in methanol (20 mL) was added 4 N hydrogen chloride in dioxane (8 mL). The mixture was stirred overnight at room temperature. Undissolved solid was filtered off, and the filtrate was concentrated to give the product as yellow solid 0.5 g; MS (EI): m/e=232.0 [M+H]+.

후처리

  1. filtrationwas filtered off
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-abb0d60a5d7047a485f8d8066952afef
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321727B2

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