Phosphate → 2-Phenyl-4,5-dihydro-1,3-thiazole-4-carboxylic acid
반응식
[C:1](#[N:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N[C@H:10]([C:13]([OH:15])=[O:14])[CH2:11][SH:12].P([O-])([O-])([O-])=O>CO>[C:2]1([C:1]2[S:12][CH2:11][CH:10]([C:13]([OH:15])=[O:14])[N:8]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1참가 물질
5
반응 조건
- 온도
- 40 °C
실험 절차
Benzonitrile (40 mmol) was combined with L-cysteine (45 mmol) in 100 mL of 1:1 MeOH/pH 6.4 phosphate buffer solution. The reaction was stirred at 40° C. for 3 days. The precipitate was removed by filtration, and MeOH was removed using rotary evaporation. To the remaining solution was added 1M HCl to adjust to pH=2 under 0° C. The resulting precipitate was filtered to yield a white solid 2-phenyl-4,5-dihydrothiazole-4-carboxylic acid 42a, which was used directly to next step without purification.
후처리
- customThe precipitate was removed by filtration, and MeOH
- customwas removed
- customevaporation
- additionTo the remaining solution was added 1M HCl
- customto adjust to pH=2 under 0° C
- filtrationThe resulting precipitate was filtered
출처 및 근거
- ORD 기록
- ord-6548f0433bdd4c3c9ebe2ed0cfadbf32
- 출처 데이터셋
- uspto-grants-2016_09
- 특허 번호
- US09447049B2
반응 노트
불러오는 중…