2,2,2-Trifluoro-1-(pyridin-2-yl)ethan-1-amine → 5-Cyclopropyl-6-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (2,2,2-trifluoro-1-pyridin-2-yl-ethyl)-amide

HRID 632362

반응식

HRID 632362 반응식
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:16]([OH:18])=O)=[N:8][C:9]=2[O:10][CH2:11][C:12]([F:15])([F:14])[F:13])[CH2:3][CH2:2]1.[F:19][C:20]([F:30])([F:29])[CH:21]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=1)[NH2:22]>>[F:30][C:20]([F:19])([F:29])[CH:21]([NH:22][C:16]([C:7]1[CH:6]=[CH:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][C:12]([F:13])([F:14])[F:15])[N:8]=1)=[O:18])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=1

참가 물질

3

반응물 2

HCID 252199112,2,2-Trifluoro-1-(pyridin-2-yl)ethan-1-amineHCID 710876495-Cyclopropyl-6-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid

생성물 1

HCID 866747905-Cyclopropyl-6-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (2,2,2-trifluoro-1-pyridin-2-yl-ethyl)-amide

실험 절차

The title compound was synthesized in analogy to Example 280c, using 5-cyclopropyl-6-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (Example 301a) and 2,2,2-trifluoro-1-(pyridin-2-yl)ethanamine (CAN 35272-15-2) as starting materials, MS (EI): m/e=420.1 [M+H]+.

출처 및 근거

ORD 기록
ord-d81a211e5e3549528c5c9bf9b43865a0
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321727B2

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