Lithium Hydroxide → 6-((4-Fluorophenyl)(hydroxy)methyl)picolinic acid

HRID 632384노트

반응식

HRID 632384 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:19])[C:9]2[N:14]=[C:13]([C:15]([O:17]C)=[O:16])[CH:12]=[CH:11][CH:10]=2)=[CH:4][CH:3]=1.[OH-].[Li+]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([OH:19])[C:9]2[N:14]=[C:13]([C:15]([OH:17])=[O:16])[CH:12]=[CH:11][CH:10]=2)=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 3939Lithium HydroxideHCID 71087862Methyl 6-((4-fluorophenyl)(hydroxy)methyl)picolinate

생성물 1

HCID 710873416-((4-Fluorophenyl)(hydroxy)methyl)picolinic acid

실험 절차

In analogy to the procedure described in Example 5 c), methyl 6-((4-fluorophenyl)(hydroxy)methyl)picolinate was saponified with lithium hydroxide to obtain the title compound. MS (EI): m/e=246.1 [M−H]−.

출처 및 근거

ORD 기록
ord-e9f1113113ce4aa38782f3b4c7821a1d
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321727B2

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