Hydrochloric Acid → 2-cyclopentyl N-piperidin-3-yl-L-leucinate dihydrochloride

HRID 632561노트

반응식

HRID 632561 반응식
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([NH:14][C@H:15]([C:20]([O:22][CH:23]2[CH2:27][CH2:26][CH2:25][CH2:24]2)=[O:21])[CH2:16][CH:17]([CH3:19])[CH3:18])[CH2:9]1)=O)(C)(C)C.[ClH:28]>ClCCl.O1CCOCC1>[ClH:28].[ClH:28].[NH:8]1[CH2:13][CH2:12][CH2:11][CH:10]([NH:14][C@H:15]([C:20]([O:22][CH:23]2[CH2:24][CH2:25][CH2:26][CH2:27]2)=[O:21])[CH2:16][CH:17]([CH3:19])[CH3:18])[CH2:9]1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 866864133-((S)-1-cyclopentyloxycarbonyl-3-methyl-butylamino)-piperidine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 866864142-cyclopentyl N-piperidin-3-yl-L-leucinate dihydrochloride수율 24%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 312751,4-Dioxane용매

실험 절차

To a solution of 3-((S)-1-cyclopentyloxycarbonyl-3-methyl-butylamino)-piperidine-1-carboxylic acid tert-butyl ester (0.840 g, 2.20 mmol) in dichloromethane (5 mL) was added 4M hydrogen chloride in dioxane (10 mL). The reaction was stirred at room temperature for 90 minutes and then concentrated to give the product (184 mg, 24% yield). LC/MS: m/z 283 [M+H]+

후처리

  1. concentrationconcentrated

출처 및 근거

ORD 기록
ord-65dbc7940e7b4010826560512f4aa94a
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321718B2

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