Hydrochloric Acid → 4-bromo-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one

HRID 632740

반응식

HRID 632740 반응식
[Br:1][C:2]1[CH:7]=[N:6][C:5]([O:8]C)=[C:4]2[N:10]([S:13]([C:16]3[CH:22]=[CH:21][C:19]([CH3:20])=[CH:18][CH:17]=3)(=[O:15])=[O:14])[CH:11]=[CH:12][C:3]=12.Cl>O1CCOCC1>[Br:1][C:2]1[C:3]2[CH:12]=[CH:11][N:10]([S:13]([C:16]3[CH:22]=[CH:21][C:19]([CH3:20])=[CH:18][CH:17]=3)(=[O:15])=[O:14])[C:4]=2[C:5](=[O:8])[NH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 896575464-bromo-7-methoxy-1-tosyl-1H-pyrrolo[2,3-c]pyridine

생성물 1

HCID 896575804-bromo-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one수율 94%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

반응 조건

온도
40 °C

실험 절차

A solution of 4-bromo-7-methoxy-1-tosyl-1H-pyrrolo[2,3-c]pyridine (12.4 g, 32.6 mmol) in dioxane (140 mL) was stirred at room temperature. To this solution was added 4M HCl in dioxane (140 mL). The reaction mixture was stirred at 40° C. for 16 hours. The reaction mixture was cooled to room temperature and concentrated. The residue was triturated with diethyl ether, filtered, and rinsed with additional diethyl ether and dried to provide 4-bromo-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one (11.23 g, 30.6 mmol, 94% yield) as a beige solid.

후처리

  1. temperatureThe reaction mixture was cooled to room temperature
  2. concentrationconcentrated
  3. customThe residue was triturated with diethyl ether
  4. filtrationfiltered
  5. washrinsed with additional diethyl ether
  6. customdried

출처 및 근거

ORD 기록
ord-57595f7256514b2382a70bcb8fcd7655
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321765B2

연결된 노트

불러오는 중…