Triethylamine → N-(4-bromo-1-methyl-1H-pyrazol-3-yl)-4-chlorobutanamide

HRID 632765노트

반응식

HRID 632765 반응식
[Br:1][C:2]1[C:3]([NH2:8])=[N:4][N:5]([CH3:7])[CH:6]=1.C(N(CC)CC)C.[Cl:16][CH2:17][CH2:18][CH2:19][C:20](Cl)=[O:21].[Cl-].[NH4+]>C1COCC1>[Br:1][C:2]1[C:3]([NH:8][C:20](=[O:21])[CH2:19][CH2:18][CH2:17][Cl:16])=[N:4][N:5]([CH3:7])[CH:6]=1

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 25517Ammonium ChlorideHCID 783704-Chlorobutyryl chlorideHCID 27352834-bromo-1-methyl-1H-pyrazol-3-amine

생성물 1

HCID 118061399N-(4-bromo-1-methyl-1H-pyrazol-3-yl)-4-chlorobutanamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
0 °C

실험 절차

To a solution of 4-bromo-1-methyl-1H-pyrazol-3-amine (310 mg) and triethylamine (0.37 mL) in THF (8.8 mL) was added 4-chlorobutanoyl chloride (0.22 mL) under ice-cooling, and the mixture was stirred at 0° C. for 30 min. To the reaction mixture was added saturated aqueous ammonium chloride solution, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (456 mg).

후처리

  1. temperaturecooling
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe extract was washed with saturated brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-1d3631e8debd4ebaa2d974ef803fcf94
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321757B2

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