Phosphorus oxychloride → 4-Chloro-6-ethyl-5-iodopyrimidine

HRID 632877

반응식

HRID 632877 반응식
O[C:2]1[C:7]([I:8])=[C:6]([CH2:9][CH3:10])[N:5]=[CH:4][N:3]=1.O=P(Cl)(Cl)[Cl:13]>>[Cl:13][C:2]1[C:7]([I:8])=[C:6]([CH2:9][CH3:10])[N:5]=[CH:4][N:3]=1

참가 물질

3

반응물 2

HCID 24813Phosphorus oxychlorideHCID 1784377446-ethyl-5-iodo-1H-pyrimidin-4-one

생성물 1

HCID 109784874-Chloro-6-ethyl-5-iodopyrimidine

반응 조건

온도
90 °C

실험 절차

A suspension of 90 g (0.36 mol) 4-hydroxy-5-iodo-6-ethyl pyrimidine in 600 mL POCl3 is heated for 1 h at 90° C. The reaction mixture is concentrated under reduced pressure and the residue is poured into crushed ice. The precipitated solid is collected by filtration and washed with water. After drying, the desired product is obtained as a solid (65 g; 67%).

후처리

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. additionthe residue is poured
  3. custominto crushed ice
  4. filtrationThe precipitated solid is collected by filtration
  5. washwashed with water
  6. customAfter drying

출처 및 근거

ORD 기록
ord-183e56c017914ce48ce8cdeb73f423ed
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321771B2

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