Morpholine → HCID 58614903, 화합물

HRID 632997노트

반응식

HRID 632997 반응식
Br[CH2:2][C:3]1[CH:24]=[CH:23][C:6]([C:7]([NH:9][C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=3)[CH:11]=2)=[O:8])=[CH:5][CH:4]=1.[NH:25]1[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1>CS(C)=O>[Cl:16][C:13]1[CH:14]=[CH:15][C:10]([NH:9][C:7](=[O:8])[C:6]2[CH:23]=[CH:24][C:3]([CH2:2][N:25]3[CH2:30][CH2:29][O:28][CH2:27][CH2:26]3)=[CH:4][CH:5]=2)=[CH:11][C:12]=1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 668781704-(Bromomethyl)-N-[4-chloro-3-(2-pyridinyl)phenyl]benzamide

생성물 1

HCID 58614903HCID 58614903, 화합물

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

4-(bromomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide (85 mg) was dissolved in DMSO (1 mL) and stirred for 1 h with morpholine. The reaction mixture was concentrated, and the crude residue was purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(morpholinomethyl)benzamide. MS (Q1) 408.4 (M)+.

후처리

  1. concentrationThe reaction mixture was concentrated
  2. customthe crude residue was purified by reverse phase HPLC

출처 및 근거

ORD 기록
ord-a31484692aad4a889c9540f8cb4de17d
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321761B2

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