Hydrochloric Acid → mono N-hydroxysuccinimide glutarate

HRID 6335

반응식

HRID 6335 반응식
[C:1]1(=[O:8])[O:7][C:5](=[O:6])[CH2:4][CH2:3][CH2:2]1.[OH:9][N:10]1[C:14](=[O:15])[CH2:13][CH2:12][C:11]1=[O:16].C(N(CC)CC)C.Cl>ClCCl>[C:1]([OH:7])(=[O:8])[CH2:2][CH2:3][CH2:4][C:5]([OH:9])=[O:6].[OH:9][N:10]1[C:14](=[O:15])[CH2:13][CH2:12][C:11]1=[O:16]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 7940Glutaric anhydrideHCID 8471TriethylamineHCID 80170N-Hydroxysuccinimide

생성물 1

HCID 19793121mono N-hydroxysuccinimide glutarate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

One mole of glutaric anhydride and one mole of N-hydroxysuccinimide were treated in dichloromethane with 1.2 equivalents of triethylamine. This reaction was stirred for 40 minutes, acidified by the addition of 0.5N hydrochloric acid (HCl) (aqueous), and then extracted with ethyl acetate to form mono N-hydroxysuccinimide glutarate. This glutarate was then combined with 5 moles of thionyl chloride and stirred at room temperature for three hours. The resulting reaction mixture was dried to remove volatiles, and thereby form N-hydroxysuccinimidyl glutaryl chloride.

후처리

  1. extractionextracted with ethyl acetate

출처 및 근거

ORD 기록
ord-1ed7b4f414b94a45a886575dff6a9247
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05248611

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