Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyclohexanemethanol → 2-(Cyclohexylmethoxy)pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyclohexanemethanol | HCID 7507 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 2-Bromopyrimidine | HCID 78345 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-(Cyclohexylmethoxy)pyrimidine | HCID 86694667 | — |
반응 단계
NaH (1.1 equivalent) is added to an equimolar mixture of 2-bromopyrimidine and cyclohexylmethanol in THF. The reaction mixture is stirred at +60° C. for 18 hours, cooled to room temperature, partitioned between H2O and ethyl acetate. Organic portion is separated, dried over anhydrous Na2SO4 and concentrated under reduced pressure to give 2-(cyclohexylmethoxy)pyrimidine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09447078B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-08bcb063c6f745de8323dde4cf803480 |
| 출처 메모 | uspto-grants-2016_09 |