Hydrogen Bromide → 2-Bromo-1-(2-methylpyridin-3-yl)ethanone hydrobromide

HRID 633713노트

반응식

HRID 633713 반응식
[CH3:1][C:2]1[C:7]([C:8](=[O:10])[CH3:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[BrH:11].BrBr.C(OCC)C>C(O)(=O)C>[BrH:11].[Br:11][CH2:9][C:8]([C:7]1[C:2]([CH3:1])=[N:3][CH:4]=[CH:5][CH:6]=1)=[O:10]

참가 물질

6

반응물 4

HCID 260Hydrogen BromideHCID 3283Diethyl EtherHCID 24408BromineHCID 109424821-(2-Methylpyridin-3-yl)ethan-1-one

생성물 1

HCID 124162362-Bromo-1-(2-methylpyridin-3-yl)ethanone hydrobromide수율 85.5%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

150 mg (1.11 mmol) of 1-(2-methylpyrid-3-yl)ethanone are dissolved in 10 mL of glacial acetic acid. 365 μl (2.22 mmol) of hydrobromic acid and 63 μl (1.22 mmol) of bromine are added to the medium. The reaction mixture is placed under magnetic stirring at room temperature for 1 hour. Ethyl ether is added to the solution until a precipitate appears. The precipitate corresponding to 2-bromo-1-(2-methylpyrid-3-yl)ethanone hydrobromide is filtered off, washed with ethyl ether and dried. The 280 mg of product obtained have the following characteristics:

후처리

  1. filtrationThe precipitate corresponding to 2-bromo-1-(2-methylpyrid-3-yl)ethanone hydrobromide is filtered off
  2. washwashed with ethyl ether
  3. customdried

출처 및 근거

ORD 기록
ord-e6e8eb07b46d42bea59d555283c86b8e
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321790B2

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