Hydrochloric Acid → 5-((Azetidin-3-yloxy)methyl)thiazole hydrochloride
반응식
[ClH:1].[S:2]1[C:6]([CH2:7][O:8][CH:9]2[CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10]2)=[CH:5][N:4]=[CH:3]1>C(OCC)C>[ClH:1].[NH:11]1[CH2:12][CH:9]([O:8][CH2:7][C:6]2[S:2][CH:3]=[N:4][CH:5]=2)[CH2:10]1참가 물질
4
실험 절차
A solution of HCl in diethylether (2N, 5.5 mL) was added to a solution of tert-butyl 3-(thiazol-5-ylmethoxy)-azetidine-1-carboxylate (150 mg, 0.55 mmol) in diethylether (2 mL) at room temperature. The reaction mixture was stirred 30 minutes then concentrated to dryness. After trituration in diethyl ether (10 mL), the title compound was obtained as a yellow solid (113 mg, quantitative).
후처리
- concentrationthen concentrated to dryness
출처 및 근거
- ORD 기록
- ord-18436d2da3524894b492a962acc2dd24
- 출처 데이터셋
- uspto-grants-2016_04
- 특허 번호
- US09321769B2
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