Bromine → 2-Amino-5-bromonicotinaldehyde hydrobromide

HRID 633975

반응식

HRID 633975 반응식
[Br:1]Br.[NH2:3][C:4]1[C:9]([CH:10]=[O:11])=[CH:8][CH:7]=[CH:6][N:5]=1>C(O)(=O)C>[BrH:1].[NH2:3][C:4]1[N:5]=[CH:6][C:7]([Br:1])=[CH:8][C:9]=1[CH:10]=[O:11]

참가 물질

4

반응물 2

HCID 24408BromineHCID 7376333-Pyridinecarboxaldehyde, 2-amino-

생성물 1

HCID 866061462-Amino-5-bromonicotinaldehyde hydrobromide수율 165.3%

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

실험 절차

A solution of bromine (1.05 mL, 20.0 mmol) in acetic acid (20 mL) was added to a solution of 2-amino-3-pyridinecarboxaldehyde (2.5 g, 20 mmol) in acetic acid (50 mL) at room temperature. The reaction mixture was then stirred overnight. The resulting precipitate was filtered and washed with diethyl ether to give the title compound as a white solid (4.66 g, 80%).

후처리

  1. filtrationThe resulting precipitate was filtered
  2. washwashed with diethyl ether

출처 및 근거

ORD 기록
ord-7d7ab6aa56a64900bf92e710f3f0f273
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09321769B2

연결된 노트

불러오는 중…