Hydrochloric Acid → 3-(Morpholin-4-yl)propanoic acid

HRID 634733노트

반응식

HRID 634733 반응식
[OH-].[K+].[O:3]1[CH2:8][CH2:7][N:6]([CH2:9][CH2:10][C:11]([O:13]C)=[O:12])[CH2:5][CH2:4]1.Cl>C(O)C>[O:3]1[CH2:4][CH2:5][N:6]([CH2:9][CH2:10][C:11]([OH:13])=[O:12])[CH2:7][CH2:8]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 1013734-Morpholinepropanoic acid, methyl ester

생성물 1

HCID 4108133-(Morpholin-4-yl)propanoic acid수율 109.4%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

Potassium hydroxide (485 mg, 8.6mmol) was added to a solution of methyl 3-morpholinopropionate (1 g, 5.7 mmol) in ethanol (20 ml) and the mixture stirred for 2 hours at 80° C. The solution was allowed to cool and adjusted to pH1 with 6M hydrochloric acid. Insoluble material was removed by filtration and the volatiles removed from the filtrate by evaporation. The resulting oil was triturated with ether, the solid product collected by filtration, washed with methylene chloride and dried under vacuum to give 3-morpholinopropionic acid (993 mg, 89%) as a white solid.

후처리

  1. temperatureto cool
  2. customInsoluble material was removed by filtration
  3. customthe volatiles removed from the filtrate by evaporation
  4. customThe resulting oil was triturated with ether
  5. filtrationthe solid product collected by filtration
  6. washwashed with methylene chloride
  7. customdried under vacuum

출처 및 근거

ORD 기록
ord-86cdfda27d254be487ffcb57eed83c91
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06184225B2

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