Diazomethane → Methyl 5-methyl-4-hexenoate

HRID 634893

반응식

HRID 634893 반응식
[N+](=[CH2:3])=[N-].[CH3:4][C:5]([CH3:12])=[CH:6][CH2:7][CH2:8][C:9]([OH:11])=[O:10]>CCOCC>[CH3:4][C:5]([CH3:12])=[CH:6][CH2:7][CH2:8][C:9]([O:11][CH3:3])=[O:10]

참가 물질

4

반응물 2

HCID 9550DiazomethaneHCID 124253245-Methyl-4-hexenoic acid

생성물 1

HCID 10909672Methyl 5-methyl-4-hexenoate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

Freshly prepared diazomethane in ether was added to an ice-cooled solution of 5-methyl-4-hexenoic acid (4.5 g, 35.16 mmol) in ether (10 mL) until the solution became slightly yellow in color. The solvent was then evaporated under vacuum to afford the title product as a colorless liquid in near quantitative yield (4.90 g). This product was used in the next reaction step without further purification. 1H NMR (CDCl3) δ 1.62 & 1.68 [2s, 6H, C(CH3)2], 2.30 [m, 4H, (CH2)2], 3.69 (s, 3H, COOCH3) and 5.07 (t, 1H, CH).

후처리

  1. customThe solvent was then evaporated under vacuum

출처 및 근거

ORD 기록
ord-5c67a1c71013403db9338d06be7ae993
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06184361B2

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