Hydrogen Bromide → N-ethyl-7-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline hydrobromide

HRID 634909노트

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HRID 634909 반응식
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:13]C)[CH:11]=2)[C:6]([CH3:15])=[CH:5][C:4]1([CH3:17])[CH3:16])[CH3:2].[BrH:18]>C(O)(=O)C>[BrH:18].[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([OH:13])[CH:11]=2)[C:6]([CH3:15])=[CH:5][C:4]1([CH3:16])[CH3:17])[CH3:2]

참가 물질

4

반응물 2

HCID 260Hydrogen BromideHCID 154511021-Ethyl-7-methoxy-2,2,4-trimethyl-1,2-dihydroquinoline

생성물 1

HCID 21260952N-ethyl-7-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline hydrobromide수율 85%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

60 g (0.25 mol) N-ethyl-2,2,4-trimethyl-7-methoxy-1,2-dihydroquinoline was dissolved in 150 ml glacial acetic acid and 150 ml hydrobromic acid was added. The solution was refluxed for 24 h. The cooled solution was stirred in an ice/methanol bath. Subsequently the precipitate was filtered and washed several times with acetone. Colourless crystals were formed in a yield of 85%.

후처리

  1. temperatureThe solution was refluxed for 24 h
  2. filtrationSubsequently the precipitate was filtered
  3. washwashed several times with acetone
  4. customColourless crystals were formed in a yield of 85%

출처 및 근거

ORD 기록
ord-0e6936646cc4469fb58c7b1693219c31
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06184379B2

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