Succinic anhydride → Succinic acid Fluorenylmethyl Ester

HRID 634991

반응식

HRID 634991 반응식
[C:1]1([CH2:14][OH:15])[C:13]2[CH2:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[C:16]1(=[O:22])[O:21][C:19](=[O:20])[CH2:18][CH2:17]1>C(Cl)Cl>[C:1]1([CH2:14][O:15][C:16](=[O:22])[CH2:17][CH2:18][C:19]([OH:21])=[O:20])[C:13]2[CH2:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 7922Succinic anhydride2회HCID 523071-Fluorenemethanol

생성물 1

HCID 69916676Succinic acid Fluorenylmethyl Ester

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Fluorenemethanol (10.0 g, 51.0 mmol) was dissolved in 150 ml CH2Cl2, and succinic anhydride (5.6 g, 56 mmol) was added. The solution was stirred for 6 h, and a further portion of succinic anhydride (2.5 g, 25 mmol) was added, and stirring continued overnight. The reaction appeared complete by TLC. The solvent was then removed, and the residue extracted with ethyl acetate, washed with 1% HCl, water, brine, dried (MgSO4) and evaporated to an oil which crystallized on standing. A quantitative yield of crude product was obtained which was used without further purification.

후처리

  1. stirringstirring continued overnight
  2. customThe solvent was then removed
  3. extractionthe residue extracted with ethyl acetate
  4. washwashed with 1% HCl, water, brine
  5. dry with materialdried (MgSO4)
  6. customevaporated to an oil which
  7. customcrystallized on standing

출처 및 근거

ORD 기록
ord-64843d96446146ccb080137976478364
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06184389B2

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