p-Aminoacetophenone → 4-(4-Acetylphenyl)amino-3-nitropyridine hydrochloride
반응식
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][N:6]=[CH:5][C:4]=1[N+:9]([O-:11])=[O:10].[NH2:12][C:13]1[CH:18]=[CH:17][C:16]([C:19](=[O:21])[CH3:20])=[CH:15][CH:14]=1>C(O)C>[ClH:2].[C:19]([C:16]1[CH:17]=[CH:18][C:13]([NH:12][C:3]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[N+:9]([O-:11])=[O:10])=[CH:14][CH:15]=1)(=[O:21])[CH3:20]참가 물질
4
실험 절차
A solution of 4-chloro-3-nitropyridine hydrochloride (9.75 g, 50 mmol) in ethanol (40 ml) was added to a slurry of p-aminoacetophenone (6.76 g, 50 ml) in ethanol (25 ml), and the mixture was stirred at room temperature overnight. The mixture was chilled in ice, and the yellow solid filtered off and dried in vacuo. Yield 10.1 g (69%), m.p. 197°-200° C.
후처리
- temperatureThe mixture was chilled in ice
- filtrationthe yellow solid filtered off
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-54ee79e104304afe86e6fd203bcf0aac
- 출처 데이터셋
- uspto-grants-1993_09
- 특허 번호
- US05248681
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