Acetic Anhydride → N-(4-Iodophenyl)acetamide

HRID 635230

반응식

HRID 635230 반응식
[I:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[C:9](OC(=O)C)(=[O:11])[CH3:10]>C(Cl)Cl>[I:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:9](=[O:11])[CH3:10])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 108934-Iodoaniline

생성물 1

HCID 12147N-(4-Iodophenyl)acetamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 4-Iodo-aniline (15 g, 69 mmol) in dry CH2Cl2 (100 ml) was added acetic anhydride(14.09 g, 138 mmol) at room temperature, the reaction mixture was then stirred for 2 hr. The gray color precipitate formed during the reaction was filtered, washed with ether and collected, the mother solution was concentrated to dryness and AcOEt was added, the resulting precipitate was filtered, washed with ether and combined with the previous solid as the desired product (15.95 g, 88.7%).

후처리

  1. customThe gray color precipitate
  2. customformed during the reaction
  3. filtrationwas filtered
  4. washwashed with ether
  5. customcollected
  6. concentrationthe mother solution was concentrated to dryness and AcOEt
  7. additionwas added
  8. filtrationthe resulting precipitate was filtered
  9. washwashed with ether

출처 및 근거

ORD 기록
ord-00f4b8765ab64c0a831636bb8ed27486
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06187792B1

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