홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Methylhydrazine → 3-(3-(4-(4chlorophenyl)piperazin-1-yl)propyl)-4,5,6,7-tetrahydro-1-methyl-1H-indazole

HRID 635324
노트
인쇄 미리보기

반응식

HRID 635324 반응식
O=[C:2]([CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C:9]1=O)[CH2:3][CH2:4][C:5](O)=O.[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)=[CH:18][CH:17]=1.ClC1C=CC(C2CCNCC2)=CC=1.[CH3:41][NH:42][NH2:43].[H-].[Al+3].[Li+].[H-].[H-].[H-].S([O-])([O-])(=O)=O.[Mg+2]>CO.O1CCCC1.C(OCC)(=O)C.O1CCCC1.O>[Cl:15][C:16]1[CH:17]=[CH:18][C:19]([N:22]2[CH2:27][CH2:26][N:25]([CH2:5][CH2:4][CH2:3][C:2]3[C:8]4[CH2:13][CH2:12][CH2:11][CH2:10][C:9]=4[N:42]([CH3:41])[N:43]=3)[CH2:24][CH2:23]2)=[CH:20][CH:21]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

11

반응물 6

HCID 6061MethylhydrazineHCID 24083Sulfuric acid magnesium salt (1:1)HCID 974781-(4-Chlorophenyl)piperazineHCID 12036134-(4-Chlorophenyl)piperidineHCID 36291314-Oxo-4-(2-oxocyclohexyl)butyric acidHCID 21226445Aluminium lithium hydride

생성물 1

HCID 21258066
3-(3-(4-(4chlorophenyl)piperazin-1-yl)propyl)-4,5,6,7-tetrahydro-1-methyl-1H-indazole

시약·촉매·용매 4

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매HCID 8857Ethyl Acetate용매HCID 21881883Oxolane--water (1/1)용매

실험 절차

This compound could be also obtained by the following method. That is, 4-(4-chlorophenyl)-1-(4-oxo-4-(2-oxocyclohexyl)butyryl)piperazine obtained by using 4-oxo4-(2-oxocyclohexyl)-n-butyric acid and 1-(4-chlorophenyl)piperazine instead of 3-(4,5,6,7-tetrahydro-2H-indazol-3-yl)propionic acid and 4-(4-chlorophenyl)piperidine used in Example 102 was refluxed under heating in a methanol solvent with methyl hydrazine. After the completion of the reaction, the solvent was evaporated under reduced pressure to give an oily substance. This compound was dissolved in tetrahydrofuran and thereto was added lithium aluminum hydride in an ice bath. After the completion of the reaction, a mixture of tetrahydrofuran—water was added, and then ethyl acetate and magnesium sulfate were further added. The reaction mixture was filtered through celite, and the solvent was evaporated under reduced pressure. The obtained residue was subjected to silica gel column chromatography to give 3-(3-(4-(4chlorophenyl)piperazin-1-yl)propyl)-4,5,6,7-tetrahydro-1-methyl-1H-indazole.

후처리

  1. temperaturewas refluxed
  2. customAfter the completion of the reaction
  3. customthe solvent was evaporated under reduced pressure
  4. customto give an oily substance
  5. customAfter the completion of the reaction
  6. additionwas added
  7. filtrationThe reaction mixture was filtered through celite
  8. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-e20f168a8ab44b99a1d47358802f3b50
출처 데이터셋
uspto-grants-2001_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06187774B1

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트