Ethyl chloroacetate → HCID 70223099, 화합물

HRID 635502노트

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HRID 635502 반응식
[C:1]([CH:5]([O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:6](Cl)=[O:7])([CH3:4])([CH3:3])[CH3:2].C([C:20]1C=CC=C[C:21]=1[O-:22])(C)(C)C.[Na+].ClCC(OCC)=O>>[C:1]([CH:5]([O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:6]([O:22][CH2:21][CH3:20])=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

4

반응물 3

HCID 7751Ethyl chloroacetateHCID 23680164Sodium 2-tert-butylphenolateHCID 86756415HCID 86756415, 화합물

생성물 1

HCID 70223099HCID 70223099, 화합물

실험 절차

The synthesis of this product required the preparation of t-butylphenoxyacetyl chloride from sodium t-butylphenoxide and ethyl chloroacetate. The ethyl t-butylphenoxyacetate obtained is cleaved with potassium hydroxide in order to liberate the t-butylphenoxyacetic acid. The acid chloride is obtained by heating this acid in thionyl chloride. After removing the excess thionyl chloride, the t-butylphenoxyacetyl chloride is reacted with deoxyguanosine according to the procedure described by SCHULHOF et al. for 2-N-phenoxyacetyldeoxyguanosine [Nucleic Acids Res., 15(2), p. 397-415, (1987)].

후처리

  1. customThe synthesis of this product

출처 및 근거

ORD 기록
ord-f0e45b5caae2421795f409aed45a2bad
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06187914B1

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