Phosphorus sulfide (P2S5) → HCID 21256521, 화합물

HRID 635794노트

반응식

HRID 635794 반응식
[CH2:1]([CH:3]1[C:8](=O)[NH:7][C:6]2[CH:10]=[CH:11][CH:12]=[CH:13][C:5]=2[O:4]1)[CH3:2].P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:15]>N1C=CC=CC=1>[CH2:1]([CH:3]1[C:8](=[S:15])[NH:7][C:6]2[CH:10]=[CH:11][CH:12]=[CH:13][C:5]=2[O:4]1)[CH3:2]

참가 물질

4

반응물 2

HCID 14817Phosphorus sulfide (P2S5)HCID 31555992-Ethyl-2H-benzo[b][1,4]oxazin-3(4H)-one

생성물 1

HCID 21256521HCID 21256521, 화합물수율 532.7%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

0.25 g of 2-ethyl-1,4-benzoxazin-3-one is stirred in 2 ml of pyridine with 95 mg of phosphorus pentasulfide. The reaction is completed by reflux-boiling. It is poured onto water, extracted with ethyl acetate, and the organic phase is washed with brine. It is dried with magnesium sulfate and concentrated by evaporation. After column chromatography with hexane/ethyl acetate, 220 mg of product results.

후처리

  1. temperatureby reflux-boiling
  2. additionIt is poured onto water
  3. extractionextracted with ethyl acetate
  4. washthe organic phase is washed with brine
  5. dry with materialIt is dried with magnesium sulfate
  6. concentrationconcentrated by evaporation

출처 및 근거

ORD 기록
ord-97f59d314a304465accf2e88423a266d
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06191127B1

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