Acetic Anhydride → 2-Acetyl-1,2,4-triazine-3,5(2H,4H)-dione

반응식

[N:1]1[NH:2][C:3](=[O:8])[NH:4][C:5](=[O:7])[CH:6]=1.[C:9](OC(=O)C)(=[O:11])[CH3:10]>>[C:9]([N:2]1[C:3](=[O:8])[NH:4][C:5](=[O:7])[CH:6]=[N:1]1)(=[O:11])[CH3:10]

참가 물질

반응물 2

HCID 7918Acetic Anhydride

HCID 680371,2,4-Triazine-3,5(2H,4H)-dione

생성물 1

HCID 212565952-Acetyl-1,2,4-triazine-3,5(2H,4H)-dione

실험 절차

2H-[1,2,4]Triazin-3,5-dione (100 g, 884 mmol) is placed in 600 ml of acetic anhydride at reflux for 1.5 h. The reaction mixture is subsequently concentrated to dryness and the solid obtained is triturated in toluene. After filtering and rinsing with toluene, 130.5 g of beige crystals are isolated.

후처리

temperatureat reflux for 1.5 h
concentrationThe reaction mixture is subsequently concentrated to dryness
customthe solid obtained
customis triturated in toluene
filtrationAfter filtering
washrinsing with toluene, 130.5 g of beige crystals
customare isolated

출처 및 근거

ORD 기록: ord-a31f88d4691e424dbd6d44686bd27d99
출처 데이터셋: uspto-grants-2001_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06191130B1

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