Water → 1-Butyl-2-oxo-quinoline-4-carboxylic acid
반응식
[CH2:1]([N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([C:15]([O:17]CCCC)=[O:16])=[CH:7][C:6]1=[O:22])[CH2:2][CH2:3][CH3:4].[OH-].[Na+].O>O1CCOCC1>[CH2:1]([N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([C:15]([OH:17])=[O:16])=[CH:7][C:6]1=[O:22])[CH2:2][CH2:3][CH3:4]참가 물질
5
실험 절차
A mixture of 2.04 g (6.77 mmols) of Compound b, 0.54 g of sodium hydroxide, 40 ml of water and 40 mt of dioxane was stirred at room temperature for 30 minutes. After concentration under reduced pressure, the residue was purified by silica gel column chromatography (eluting solvent: chloroform/methanol=5/1) to give 1.44 g (yield: 87%) of Compound a.
후처리
- concentrationAfter concentration under reduced pressure
- customthe residue was purified by silica gel column chromatography (eluting solvent: chloroform/methanol=5/1)
출처 및 근거
- ORD 기록
- ord-0b7ac1002a9c48df9ec7bd4af81498e1
- 출처 데이터셋
- uspto-grants-1993_09
- 특허 번호
- US05248684
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