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Water → 5-bromo-6-chloro-2-(1H-indazol-1-yl)-N-(prop-2-ynyl)pyrimidine-4-amine

HRID 63608
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HRID 63608 반응식
[Br:1][C:2]1[C:3]([NH:12][CH2:13][C:14]#[CH:15])=[N:4][C:5](S(C)=O)=[N:6][C:7]=1[Cl:8].[NH:16]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:18]=[N:17]1.C(=O)([O-])[O-].[Cs+].[Cs+].O>CS(C)=O>[Br:1][C:2]1[C:3]([NH:12][CH2:13][C:14]#[CH:15])=[N:4][C:5]([N:16]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH:18]=[N:17]2)=[N:6][C:7]=1[Cl:8]
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참가 물질

6

반응물 4

HCID 962WaterHCID 92211H-IndazoleHCID 10796Cesium carbonateHCID 903037735-bromo-6-chloro-2-(methylsulfinyl)-N-(prop-2-ynyl)pyrimidine-4-amine2회

생성물 1

HCID 903037695-bromo-6-chloro-2-(1H-indazol-1-yl)-N-(prop-2-ynyl)pyrimidine-4-amine

시약·촉매·용매 1

HCID 679
Dimethyl Sulfoxide
용매

실험 절차

To a suspension of 0.5 g (1.62 mmol) of 5-bromo-6-chloro-2-(methylsulfinyl)-N-(prop-2-ynyl)pyrimidine-4-amine (intermediate 31) in 2 ml of DMSO, 0.19 g (1.62 mmol) indazole and 0.32 g of cesium carbonate were added. The slightly yellow solution was stirred at room temperature for 20 minutes. The reaction mixture was poured onto 10 ml of cold water. The resulting precipitate was filtered, washed with cold water and dried. The desired product was obtained as a white solid 0.31 g (52.8%).

후처리

  1. additionwere added
  2. filtrationThe resulting precipitate was filtered
  3. washwashed with cold water
  4. customdried

출처 및 근거

ORD 기록
ord-72ce7ae0ea644282b459e72d34d41508
출처 데이터셋
uspto-grants-2016_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09447095B2

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