Sulfuric Acid → 3-Nitropyridin-2-ylamine

HRID 636544

반응식

HRID 636544 반응식
ClC1C=CC=C[N:3]=1.S(=O)(=O)(O)O.Cl[C:14]1[C:19]([N+:20]([O-:22])=[O:21])=[CH:18][CH:17]=[CH:16][N:15]=1.C([O-])(=O)C.[NH4+]>COCCOCCOC>[NH2:3][C:14]1[C:19]([N+:20]([O-:22])=[O:21])=[CH:18][CH:17]=[CH:16][N:15]=1

참가 물질

6

반응물 4

HCID 1118Sulfuric AcidHCID 79772-ChloropyridineHCID 796132-Chloro-3-nitropyridineHCID 517165Ammonium Acetate

생성물 1

HCID 778873-Nitropyridin-2-ylamine

시약·촉매·용매 1

HCID 8150Diglyme용매

실험 절차

A general synthesis route begins with 2-chloropyridine which is nitrated in the presence of sulfuric acid to make 2-chloro-3-nitropyridine. This material is reacted with ammonium acetate in the presence of diglyme at about 160° C. to form 2-amino-3-nitropyridine which is reduced to form 2,3-diaminopyridine. The 2,3-diaminopyridine is reacted with 2-thiophenecarboxylic acid in the presence of polyphosphoric acid at about 125° C. to prepare 2-(2-thienyl)imidazolo [4,5]pyridine.

후처리

  1. customA general synthesis route

출처 및 근거

ORD 기록
ord-a5d0e9606d7b42a998db3f5e949b214e
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06194430B1

연결된 노트

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