2-Fluoronicotinic acid → HCID 21255180, 화합물

HRID 636557

반응식

HRID 636557 반응식
[S:1]1[CH:5]=[C:4]([C:6]([OH:8])=[O:7])[N:3]=[CH:2]1.[F:9][C:10]1[N:18]=[CH:17][CH:16]=[CH:15][C:11]=1[C:12](O)=[O:13]>>[F:9][C:10]1[N:18]=[CH:17][CH:16]=[CH:15][C:11]=1[C:12]([N:3]1[C:4]([C:6]([OH:8])=[O:7])=[CH:5][S:1][CH2:2]1)=[O:13]

참가 물질

3

반응물 2

HCID 960892-Fluoronicotinic acidHCID 3042714-Thiazolecarboxylic acid

생성물 1

HCID 21255180HCID 21255180, 화합물수율 41.3%

실험 절차

N-(2-Fluoronicotinoyl)thiazole-4-carboxylic acid is prepared as described in Example 5 from 11.03 g of thiazole-4-carboxylic acid and 11.7 g of 2-fluoronicotinic acid. 8.7 g of N-(2-fluoronicotinoyl)thiazole-4-carboxylic acid are thus obtained in the form of a cream solid. (Rf=0.33; thin layer chromatography on silica gel; eluent: ethyl acetate/acetic acid, 90/10 by volume).

후처리

  1. customN-(2-Fluoronicotinoyl)thiazole-4-carboxylic acid is prepared

출처 및 근거

ORD 기록
ord-f02f7051a7cb493fb766c2df78543567
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06194426B1

연결된 노트

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