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N-bromobutanimide → 4-Bromo-2-isopropyl-1-methoxybenzene

HRID 636711
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인쇄 미리보기

반응식

HRID 636711 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]([CH3:11])[CH3:10].[Br:12]N1C(=O)CCC1=O>C(#N)C>[CH:9]([C:4]1[CH:5]=[C:6]([Br:12])[CH:7]=[CH:8][C:3]=1[O:2][CH3:1])([CH3:11])[CH3:10]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 2706232-Isopropylanisole

생성물 1

HCID 146987944-Bromo-2-isopropyl-1-methoxybenzene수율 82%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of 2-methoxyisopropyl-benzene (2 g) and N-bromosuccinimide (2.6 g) in acetonitrile (20 mL) was stirred at ambient temperature for 18 h. The reaction was concentrated in vacuo, slurried in carbon tetrachloride and filtered. The filtrate was concentrated in vacuo. The residue was flash chromatographed (5% dichloromethane/hexanes) to afford the title compound as an oil (2.5 g).

후처리

  1. concentrationThe reaction was concentrated in vacuo
  2. filtrationfiltered
  3. concentrationThe filtrate was concentrated in vacuo
  4. customchromatographed (5% dichloromethane/hexanes)

출처 및 근거

ORD 기록
ord-8d97fdb2355a424cbaee142aeb8bcfbe
출처 데이터셋
uspto-grants-2001_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06194454B1

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