Benzenesulfonyl chloride → HCID 70224730, 화합물

반응식

[CH:1]12[CH:6]([N:7]3[C:11](=[O:12])[C:10]([CH2:19][C:20]4[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=4)([CH2:13][C:14]4[CH:18]=[CH:17][S:16][CH:15]=4)[NH:9][C:8]3=[CH:26][C:27]([C:29]3[CH:36]=[CH:35][C:32]([C:33]#[N:34])=[CH:31][CH:30]=3)=[O:28])[CH:5]1[CH2:4][NH:3][CH2:2]2.[C:37]1([S:43](Cl)(=[O:45])=[O:44])[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1>>[C:37]1([S:43]([N:3]2[CH2:4][CH:5]3[CH:1]([CH:6]3[N:7]3[C:11](=[O:12])[C:10]([CH2:19][C:20]4[CH:21]=[CH:22][N:23]=[CH:24][CH:25]=4)([CH2:13][C:14]4[CH:18]=[CH:17][S:16][CH:15]=4)[NH:9][C:8]3=[CH:26][C:27]([C:29]3[CH:30]=[CH:31][C:32]([C:33]#[N:34])=[CH:35][CH:36]=3)=[O:28])[CH2:2]2)(=[O:45])=[O:44])[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1

참가 물질

반응물 2

HCID 7369Benzenesulfonyl chloride

HCID 70222813HCID 70222813, 화합물

생성물 1

HCID 70224730HCID 70224730, 화합물

실험 절차

According to the procedure of Example 13, the title compound of 37A (60 mg, 0.12 mmol) and benzenesulfonyl chloride (0.023 ml, 0.18 mmol) were reacted to generate the title compound as a white solid (58 mg, 0.091 mmol, 76% yield).

출처 및 근거

ORD 기록: ord-894f1c63cabc4c6896f0845f3f60be04
출처 데이터셋: uspto-grants-2001_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06194438B1

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