Sulfuryl chloride → 2,3-dihydro-5H-benzo[f][1,4]oxazepine-4-sulfonyl chloride

HRID 636953노트

반응식

HRID 636953 반응식
[O:1]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[CH2:5][NH:4][CH2:3][CH2:2]1.[S:12](Cl)([Cl:15])(=[O:14])=[O:13].C(N(C(C)C)C(C)C)C.COC1C=C2C(CCN(S(Cl)(=O)=O)C2)=CC=1>>[O:1]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[CH2:5][N:4]([S:12]([Cl:15])(=[O:14])=[O:13])[CH2:3][CH2:2]1

참가 물질

5

반응물 4

HCID 24648Sulfuryl chlorideHCID 81531DiisopropylethylamineHCID 218827752,3,4,5-Tetrahydro-1,4-benzoxazepineHCID 226656767-methoxy-3,4-dihydro-1H-isoquinoline-2-sulfonyl chloride

생성물 1

HCID 226657772,3-dihydro-5H-benzo[f][1,4]oxazepine-4-sulfonyl chloride

실험 절차

This compound was prepared from 1.5 g of 2,3,4,5-tetrahydro-benzo[f][1,4]oxazepine, 0.81 mL of sulfuryl chloride and 1.8 mL of ethyl diisopropyl amine using the procedure described for 63f. Yield: 0.3 g (oil), EI-MS: 247 (M+).

출처 및 근거

ORD 기록
ord-451befc9eacd48408744e619c852f3af
출처 데이터셋
uspto-grants-2001_02
특허 번호
US06194409B1

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