3-(Trifluoromethyl)aniline → (3-(Trifluoromethyl)phenyl)hydrazine

HRID 637319

반응식

HRID 637319 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:6][CH:7]=1.[N:12]([O-])=O.[Na+]>O.Cl>[F:11][C:8]([F:9])([F:10])[C:4]1[CH:3]=[C:2]([NH:1][NH2:12])[CH:7]=[CH:6][CH:5]=1

참가 물질

5

반응물 2

HCID 73753-(Trifluoromethyl)anilineHCID 23668193Sodium Nitrite

생성물 1

HCID 98650(3-(Trifluoromethyl)phenyl)hydrazine

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매2회HCID 962Water용매

실험 절차

m-Aminobenzotrifluoride (48.34 g: 0.3 mole) was cooled and treated with concentrated hydrochloric acid (137 ml) added dropwise. The paste was stirred at 0° and a solution of sodium nitrite (19.1 g) in water (137 ml) was added at 0°-5° with stirring. An almost clear solution was obtained. Then a solution of stannous chloride dihydrate (191.3 g) in concentrated hydrochloric acid (137 ml) was added dropwise with stirring at 0°-10°.

후처리

  1. additionadded dropwise
  2. stirringwith stirring
  3. customAn almost clear solution was obtained
  4. stirringwith stirring at 0°-10°

출처 및 근거

ORD 기록
ord-d5c0c161ef6a41f88e4b63776bbf63ea
출처 데이터셋
uspto-grants-1985_12
특허 번호
US04556671

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