Hydrochloric Acid → 2-(2-Ureidophenyl)acetic acid

HRID 637358노트

반응식

HRID 637358 반응식
C1(C([NH:9][C:10]([N:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH2:14][C:13]2=[O:21])=[O:11])=O)CCCCC1.Cl.[OH-:23].[K+]>>[NH:12]([C:20]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[CH2:14][C:13]([OH:21])=[O:23])[C:10]([NH2:9])=[O:11]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 13647650N-cyclohexylcarbonyl-2-oxindole-1-carboxamide

생성물 1

HCID 136476542-(2-Ureidophenyl)acetic acid

실험 절차

A slurry of 2.9 g (0.01 mole) of N-cyclohexylcarbonyl-2-oxindole-1-carboxamide in 50 ml of 1N potassium hydroxide solution was stirred at room temperature for ca. 30 minutes, during which time the solid went into solution. At this point, the reaction mixture was acidified with concentrated hydrochloric acid, with ice cooling, and then it was extracted with ethyl acetate. The extracts were washed with saturated sodium chloride solution, dried (Na2SO4) and evaporated in vacuo to give an oily solid. The oily solid was washed with diisopropyl ether and then it was recrystallized from ethanol to give 70 mg of the title compound, m.p. 174.5° C. (dec.).

후처리

  1. extractionit was extracted with ethyl acetate
  2. washThe extracts were washed with saturated sodium chloride solution
  3. dry with materialdried (Na2SO4)
  4. customevaporated in vacuo
  5. customto give an oily solid
  6. washThe oily solid was washed with diisopropyl ether
  7. customit was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-b4b20e9e890c4e5fbb8aadcd9a821438
출처 데이터셋
uspto-grants-1985_12
특허 번호
US04556672

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