Sodium Cyanide → 2-(2-Fluorophenyl)propanenitrile

HRID 637613노트

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HRID 637613 반응식
[C-:1]#[N:2].[Na+].[F:4][C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[CH:7](Cl)[CH3:8]>CS(C)=O>[F:4][C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[CH:7]([C:1]#[N:2])[CH3:8]

참가 물질

4

반응물 2

HCID 8929Sodium CyanideHCID 135643251-(1-Chloroethyl)-2-fluorobenzene

생성물 1

HCID 133880122-(2-Fluorophenyl)propanenitrile수율 85.1%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

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온도
90 °C

실험 절차

In 300 ml of dimethyl sulfoxide was dissolved 35 g of sodium cyanide by heating at 90° C., and 45 g of 2-fluoro-α-methylbenzyl chloride was added. The mixture was stirred at 90° C. for 4 hours, and then cooled. Ice-water was added and the mixture was extracted with n-hexane. The n-hexane layer was washed with water and dried over anhydrous magnesium sulfate and the solvent was evaporated off. The residue obtained was purified by distillation under reduced pressure to afford 36 g of 2-fluoro-α-methylbenzyl cyanide, b.p.0.5 55° C.

후처리

  1. temperaturecooled
  2. extractionthe mixture was extracted with n-hexane
  3. washThe n-hexane layer was washed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customthe solvent was evaporated off
  6. customThe residue obtained
  7. distillationwas purified by distillation under reduced pressure

출처 및 근거

ORD 기록
ord-b4950e3dd7e146fd8c32b508fa2be13f
출처 데이터셋
uspto-grants-1985_12
특허 번호
US04557871

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