Chloroacetaldehyde → 4,5,6,7-Tetrahydro-1-benzofuran-4-one

HRID 637782

반응식

HRID 637782 반응식
[C:1]1(=[O:8])[CH2:6][CH2:5][CH2:4][C:3](=[O:7])[CH2:2]1.C(=O)([O-])[O-].[K+].[K+].Cl[CH2:16][CH:17]=O>O>[O:7]=[C:3]1[C:2]2[CH:16]=[CH:17][O:8][C:1]=2[CH2:6][CH2:5][CH2:4]1

참가 물질

5

반응물 3

HCID 33ChloroacetaldehydeHCID 104341,3-CyclohexanedioneHCID 11430Potassium Carbonate

생성물 1

HCID 27335414,5,6,7-Tetrahydro-1-benzofuran-4-one수율 68%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a mixture of 1.12 g (10 mmoles) of 1,3-cyclohexanedione and 8 ml of water was added 1.38 g (10 mmoles) of potassium carbonate, and then 2 ml of 40% aqueous solution of chloroacetaldehyde was added thereto. The resulting mixture was stirred at a room temperature for 45 hours. The reaction mixture was maintained at a pH of from 7.75 to 9.50 throughout the reaction. After completing the reaction, the obtained reaction mixture was treated and analyzed in the same manner as in Example 1. It was proved from the results of the analysis that 4-oxo-4,5,6,7-tetrahydrobenzofuran was produced in a 68% yield.

후처리

  1. temperatureThe reaction mixture was maintained at a pH of from 7.75 to 9.50 throughout the reaction
  2. customthe reaction
  3. customthe obtained reaction mixture
  4. additionwas treated

출처 및 근거

ORD 기록
ord-3acf00d91bd24845bfb054d1ec170446
출처 데이터셋
uspto-grants-1985_12
특허 번호
US04558143

연결된 노트

불러오는 중…