Dimethylformamide → Idebenone

HRID 637896

반응식

HRID 637896 반응식
CN(C)[CH:3]=[O:4].[OH:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]1[C:22]([OH:23])=[C:21]([O:24][CH3:25])[C:20]([O:26][CH3:27])=[CH:19][C:18]=1C>N1C=CC=CC=1>[OH:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]1[C:22](=[O:23])[C:21]([O:24][CH3:25])=[C:20]([O:26][CH3:27])[C:3](=[O:4])[C:18]=1[CH3:19]

참가 물질

4

반응물 2

HCID 6228DimethylformamideHCID 128241262-(10-Hydroxydecyl)-5,6-dimethoxy-3-methylphenol

생성물 1

HCID 3686Idebenone

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a dimethylformamide solution (30 ml) of 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methylphenol (1.6 g) are added bis(3-methoxysalicylidene)ethylenediiminocobalt(II) (0.06 g) and pyridine (10 mg), and the mixture is stirred in air streams at atmospheric temperature and pressure for 72 hours. After the reaction has been completed, the reaction product is isolated in the same manner as described in Example 7. The crude crystals thus obtained are recrystallized from ether-hexane (1:3). The above procedure yields 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone (1.1 g) as orange-yellow needles melting at 51° C.-53° C.

후처리

  1. customthe reaction product is isolated in the same manner
  2. customThe crude crystals thus obtained
  3. customare recrystallized from ether-hexane (1:3)

출처 및 근거

ORD 기록
ord-b1379a744dad4c438cebfe3f8016b01d
출처 데이터셋
uspto-grants-1985_12
특허 번호
US04559177

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