Dimethylformamide dimethyl acetal → 1,5-dimethyl-1,6-naphthyridin-2(1H)-one
반응식
[CH3:1][C:2]1[N:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6](=[O:12])[NH:7]2.[CH3:13]OC(OC)N(C)C>CN(C)C=O>[CH3:13][N:7]1[C:8]2[C:3](=[C:2]([CH3:1])[N:11]=[CH:10][CH:9]=2)[CH:4]=[CH:5][C:6]1=[O:12]참가 물질
4
실험 절차
A mixture containing 4.5 g of 5-methyl-1,6-naphthyridin-2(1H)-one, 15 ml of dimethylformamide and 4 ml of dimethylformamide dimethyl acetal was stirred at room temperature overnight, then heated on a steam bath for 7 hours and then evaporated to dryness on a rotary evaporator. The solid residue was recrystallized from isopropyl alcohol and dried at 90°-95° C. to yield 3.5 g of 1,5-dimethyl-1,6-naphthyridin-2(1H)-one, m.p. 203°-205° C.
후처리
- temperatureheated on a steam bath for 7 hours
- customevaporated to dryness on a rotary evaporator
- customThe solid residue was recrystallized from isopropyl alcohol
- customdried at 90°-95° C.
출처 및 근거
- ORD 기록
- ord-6c27ef1239c546e7856e5d12b96a5df6
- 출처 데이터셋
- uspto-grants-1985_12
- 특허 번호
- US04559347
반응 노트
불러오는 중…