Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Methylisonicotinamide → N-methylpiperidine-4-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Methylisonicotinamide | HCID 96707 | — |
| 촉매 | Platinum oxide (PtO) | HCID 82844 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | N-methylpiperidine-4-carboxamide | HCID 2760460 | 98.1% |
반응 단계
A mixture of 20 g (0.147 mol) of N-methylisonicotinamide, 100 ml of ethanol, and 1.2 g of platinum oxide was hydrogenated in a Parr shaker at 60° and 60 psi for 8 hr. The catalyst was filtered off, and the filtrate was concentrated in vacuo. The residue was crystallized from ether to give 20.5 g of crude product, mp 115°-121°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04560692 |
| 출처 데이터셋 | uspto-grants-1985_12 |
| ORD ID | ord-7609ca3b91264308ad7fcd434dc646b5 |
| 출처 메모 | uspto-grants-1985_12 |