Hydrazine hydrate (1:1) → 1-Amino-3-(2,2,2-trifluoroethyl)imidazolidin-2-one

HRID 63833노트

반응식

HRID 63833 반응식
Cl[CH2:2][CH2:3][N:4]([CH2:14][C:15]([F:18])([F:17])[F:16])[C:5](=O)[O:6]C1C=CC=CC=1.[NH2:19][NH2:20].O>C(O)C>[NH2:19][N:20]1[CH2:2][CH2:3][N:4]([CH2:14][C:15]([F:18])([F:17])[F:16])[C:5]1=[O:6]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 118047012Phenyl N-(2-chloroethyl)-N-(2,2,2-trifluoroethyl)carbamate

생성물 1

HCID 867756191-Amino-3-(2,2,2-trifluoroethyl)imidazolidin-2-one

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Into a 250-mL round-bottom flask, was placed a solution of phenyl N-(2-chloroethyl)-N-(2,2,2-trifluoroethyl)carbamate (5.6 g, 19.88 mmol, 1.00 equiv) in ethanol (100 mL), NH2NH2.H2O (10 mL, 80%). The resulting solution was heated to reflux overnight in an oil bath. The resulting mixture was concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate (1:1). This resulted in 0.8 g (22%) of 1-amino-3-(2,2,2-trifluoroethyl)imidazolidin-2-one as colorless oil. (ES, m/z): 184 [M+H]+

후처리

  1. customInto a 250-mL round-bottom flask, was placed
  2. temperatureThe resulting solution was heated
  3. temperatureto reflux overnight in an oil bath
  4. concentrationThe resulting mixture was concentrated under vacuum
  5. customThis resulted in 0.8 g (22%) of 1-amino-3-(2,2,2-trifluoroethyl)imidazolidin-2-one as colorless oil

출처 및 근거

ORD 기록
ord-bde14ba1044f4cf1886949c643ee5a50
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447084B2

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