Benzoyl chloride → HCID 20252446, 화합물

HRID 638508노트

반응식

HRID 638508 반응식
[F:1][C:2]([F:28])([F:27])[C:3]1[CH:26]=[CH:25][C:6]([O:7][C:8]2[CH:24]=[CH:23][C:11]([O:12][CH:13]([CH3:22])[CH:14]([OH:21])[CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1.[C:29](Cl)(=[O:36])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1.C(N(CC)CC)C>C(Cl)Cl>[F:1][C:2]([F:27])([F:28])[C:3]1[CH:4]=[CH:5][C:6]([O:7][C:8]2[CH:24]=[CH:23][C:11]([O:12][CH:13]([CH3:22])[CH:14]([O:21][C:29](=[O:36])[C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:10][CH:9]=2)=[CH:25][CH:26]=1

참가 물질

5

반응물 3

HCID 7412Benzoyl chlorideHCID 8471TriethylamineHCID 12856783Ethyl 4-[4-(4-trifluoromethylphenoxy)phenoxy]-3-hydroxypentanoate

생성물 1

HCID 20252446HCID 20252446, 화합물수율 92%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

2.5 g of ethyl 4-[4-(4-trifluoromethylphenoxy)phenoxy]-3-hydroxypentanoate were refluxed with 1.2 min. of benzoyl chloride in 60 ml of methylene chloride in the presence of 1.3 ml of triethylamine for 1(1/2) hours. The product was diluted with methylene chloride washed with water, 1M HCl and brine and dried over MgSO4. The product was purified by silica gel chromatography (total yield 92%) and was identified as a mixture of two stereoisomers of the above ethyl benzoyloxypentanoate.

후처리

  1. washwashed with water, 1M HCl and brine
  2. dry with materialdried over MgSO4
  3. customThe product was purified by silica gel chromatography (total yield 92%)
  4. additionwas identified as a mixture of two stereoisomers of the above ethyl benzoyloxypentanoate

출처 및 근거

ORD 기록
ord-7f770c58509143f59f8ac455aef33be7
출처 데이터셋
uspto-grants-1985_12
특허 번호
US04561882

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