(4-Bromobutoxy)benzene → 1-(2-Phenoxyethyl)piperazine

HRID 638535

반응식

HRID 638535 반응식
[O:1]([CH2:8][CH2:9]CCBr)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([N:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)=O>CC(O)C>[O:1]([CH2:8][CH2:9][N:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 70986(4-Bromobutoxy)benzeneHCID 821911-Piperazinecarboxaldehyde

생성물 1

HCID 2331871-(2-Phenoxyethyl)piperazine

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

The procedure of Example 2 was repeated in entirety substituting 57.0 g (0.27 moles) of 2-bromoethyl phenyl ether for 4-phenoxybutyl bromide, using 61.6 g (0.54 moles) of 1-formylpiperazine in 300 ml of 2-propanol and refluxing the mixture for 8 hours. Evaporation of the final dried chloroform extracts gave 35 g of 1-[2-phenoxyethyl]piperazine as an oil.

후처리

  1. temperaturerefluxing the mixture for 8 hours
  2. customEvaporation of the final dried chloroform extracts

출처 및 근거

ORD 기록
ord-dad50e4304ca4efda3bc70ede21fbfed
출처 데이터셋
uspto-grants-1985_12
특허 번호
US04562189

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