Hydrochloric Acid → 2-(4-Aminophenoxy)acetic acid hydrochloride

HRID 638706

반응식

HRID 638706 반응식
C([O:3][C:4](=[O:17])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13]C(=O)C)=[CH:9][CH:8]=1)C.[ClH:18]>>[ClH:18].[NH2:13][C:10]1[CH:9]=[CH:8][C:7]([O:6][CH2:5][C:4]([OH:17])=[O:3])=[CH:12][CH:11]=1

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 309738Ethyl 2-(4-acetamidophenoxy)acetate

생성물 1

HCID 668114882-(4-Aminophenoxy)acetic acid hydrochloride수율 77.6%

반응 조건

온도
10 °C

실험 절차

A mixture (4-Acetylamino-phenoxy)-acetic acid ethyl ester 13 (375 g, 1.582 mmol), in concentrated hydrochloric acid (9.36 liters) was refluxed for 12 hours. Excess concentrated hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 14 (250 g, 77.6%) as a wheat colored powder. The melting point was found to be 224-226° C. The structure was confirmed with NMR.

후처리

  1. distillationExcess concentrated hydrochloric acid was distilled off in vacuum
  2. filtrationfiltered hot
  3. filtrationfiltered
  4. customdried

출처 및 근거

ORD 기록
ord-f28df230f2a842f6bd81173f55feb8ca
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07691364B2

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