6-(4-Nitrophenoxy)-hexanoic acid methyl ester → 6-(4-Nitrophenoxy)hexanoic acid

HRID 638740

반응식

HRID 638740 반응식
C[O:2][C:3](=[O:19])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][CH:11]=1>Cl>[N+:16]([C:13]1[CH:12]=[CH:11][C:10]([O:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]([OH:19])=[O:2])=[CH:15][CH:14]=1)([O-:18])=[O:17]

참가 물질

3

반응물 1

HCID 146502956-(4-Nitrophenoxy)-hexanoic acid methyl ester

생성물 1

HCID 223889056-(4-Nitrophenoxy)hexanoic acid수율 80.2%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A mixture of 6-(4-nitrophenoxy) hexanoic acid methyl ester 39 (125 g, 468.16 mmol) and concentrated HCl (1250 ml) was refluxed for 16 hours. The reaction mixture was cooled to room temperature, filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:6) to get pure 53 (95 g, 80.2%) as a white powder. M.p: 104-107° C.

후처리

  1. temperaturewas refluxed for 16 hours
  2. filtrationfiltered
  3. customdried
  4. customrecrystallised from a mixture of ethyl acetate:hexane (1:6)

출처 및 근거

ORD 기록
ord-bde04e64bd624a2897c80bbd9b5051a4
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07691364B2

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