Methyl iodide → 1-Bromo-5-fluoro-4-methoxy-2-nitrobenzene
반응식
[Br:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([OH:11])=[C:4]([F:12])[CH:3]=1.[C:13](=O)([O-])[O-].[K+].[K+].CI>CN(C=O)C>[CH3:13][O:11][C:5]1[CH:6]=[C:7]([N+:8]([O-:10])=[O:9])[C:2]([Br:1])=[CH:3][C:4]=1[F:12]참가 물질
5
실험 절차
A solution of 4-bromo-2-fluoro-5-nitrophenol (25 g, 106 mmol) in DMF (200 mL) was treated with potassium carbonate (28.9 g, 212 mmol) and methyl iodide (12.8 mL, 212 mmol). The reaction mixture was stirred at 60 C for 5 hours and evaporated in vacuo. The mixture was partitioned between water and ethyl acetate. The organic layer was dried over magnesium sulfate and evaporated under vacuum to afford the product (25.6 g, 97%) as a yellow solid. LC-MS (ES) (M+H)+ m/z=251.
후처리
- customevaporated in vacuo
- customThe mixture was partitioned between water and ethyl acetate
- dry with materialThe organic layer was dried over magnesium sulfate
- customevaporated under vacuum
출처 및 근거
- ORD 기록
- ord-0a3df1d3f7944ced89caa6387a12a789
- 출처 데이터셋
- uspto-grants-2010_04
- 특허 번호
- US07691850B2
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