[1,3]Oxathiolo[5,4-c]pyridin-6-ylmethanol → [1,3]Oxathiolo[5,4-c]pyridine-6-carbaldehyde

HRID 639039

반응식

HRID 639039 반응식
[S:1]1[C:9]2[CH:8]=[C:7]([CH2:10][OH:11])[N:6]=[CH:5][C:4]=2[O:3][CH2:2]1>C(Cl)Cl.[O-2].[Mn+4].[O-2]>[S:1]1[C:9]2[CH:8]=[C:7]([CH:10]=[O:11])[N:6]=[CH:5][C:4]=2[O:3][CH2:2]1

참가 물질

4

반응물 1

HCID 67426109[1,3]Oxathiolo[5,4-c]pyridin-6-ylmethanol

생성물 1

HCID 59254367[1,3]Oxathiolo[5,4-c]pyridine-6-carbaldehyde수율 62.3%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

[1,3]oxathiolo[5,4-c]pyridine-6-methanol (0.92 g, 5.44 mmole) was treated with manganese (IV) oxide (3.83 g, 44 mmole) at RT in DCM (50 mL) to afford the aldehyde (567 mg, 62%) as a solid; MS (+ve ion electrospray) m/z 168 (MH+).

출처 및 근거

ORD 기록
ord-e811c26613054254a23fc21a8c0d7428
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07691850B2

연결된 노트

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