Bromine → methyl 5-bromo-6-oxo-1H-pyrazine-3-carboxylate

HRID 639313노트

반응식

HRID 639313 반응식
[OH:1][C:2]1[N:3]=[CH:4][C:5]([C:8]([O:10][CH3:11])=[O:9])=[N:6][CH:7]=1.[Br:12]Br>C(Cl)(Cl)Cl>[CH3:11][O:10][C:8]([C:5]1[CH:4]=[N:3][C:2]([OH:1])=[C:7]([Br:12])[N:6]=1)=[O:9]

참가 물질

4

반응물 2

HCID 24408BromineHCID 178498852HCID 178498852, 화합물

생성물 1

HCID 178498844methyl 5-bromo-6-oxo-1H-pyrazine-3-carboxylate

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A mixture of 2 g (13 mmol) methyl 5-hydroxypyrazine-2-carboxylate (commercially available), 0.192 g (0.65 mmol) FeBr3, 0.7 mL (14 mmol) Br2 in 20 mL CHCl3 was refluxed for 16 h. After evaporation of all volatiles the residue was used without further purification in the consecutive step.

후처리

  1. temperaturewas refluxed for 16 h
  2. customAfter evaporation of all volatiles the residue
  3. customwas used without further purification in the consecutive step

출처 및 근거

ORD 기록
ord-d267403c5fb9427d90223a22bfd46cf5
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07691863B2

반응 노트

불러오는 중…